I ran a six-figure Amazon business myself, selling backpacks a few years ago. I regret not continuing it.
The main reason was because there was too much to do and it became really overwhelming with the volume and fulfilment.
Going back I would definitely hire VAs – something which I didn't know back then. Would've helped a lot, I couldn't afford hiring people in the UK for at least £12 per hour, so realising remote work and VAs could help would've been a life saver.
I no longer run an e-commerce business but a local services business and have hired VAs. AMA.